Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. Minor/Significance Unknown. Developing drugs is a complicated process, because no two people . Monitor Closely (1)doxepin and sulfamethoxazole both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Monitor Closely (1)gabapentin enacarbil, doxepin. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Contraindicated. Consult your healthcare professional (e.g., doctor or pharmacist) for. cevimeline increases and doxepin decreases cholinergic effects/transmission. Mechanism: unspecified interaction mechanism. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Use Caution/Monitor. Other (see comment). doxepin increases and epinephrine decreases sedation. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Either increases effects of the other by Other (see comment). Antidepressant discontinuation syndrome. Avoid or Use Alternate Drug. clozapine and doxepin both increase sedation. Avoid or Use Alternate Drug. HOW TO USE: Read the Medication Guide provided by your pharmacist before you start taking doxepin and each time you get a refill. Use Caution/Monitor. lasmiditan, doxepin. People may react differently to the same antidepressant. Avoid or Use Alternate Drug.Minor (2)doxepin, promazine. Use Caution/Monitor.doxepin and lofepramine both increase sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Mechanism: unspecified interaction mechanism. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Monitor Closely (3)doxepin decreases effects of lofexidine by unspecified interaction mechanism. Minor/Significance Unknown. Mechanism: unspecified interaction mechanism. . Avoid or Use Alternate Drug. desipramine and doxepin both increase serotonin levels. loxapine inhaled and doxepin both increase sedation. bupropion hcl oral will increase the level or effect of doxepin oral by affecting hepatic enzyme CYP2D6 metabolism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. levothyroxine increases effects of doxepin by Other (see comment). Mental health medications. Avoid or Use Alternate Drug.doxepin and imipramine both increase serotonin levels. Use Caution/Monitor. Monitor Closely (1)sufentanil and doxepin both increase sedation. Adding plans allows you to compare formulary status to other drugs in the same class. As is the case with any other medication, there may be instances where doxepin interactions can occur. Use Caution/Monitor. The site is secure. Use Caution/Monitor.doxepin and lofexidine both increase QTc interval. Minor/Significance Unknown. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Contraindicated (1)lefamulin will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Wellbutrin XL Interactions. Minor/Significance Unknown. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. A single copy of these materials may be reprinted for noncommercial personal use only. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. Avoid or Use Alternate Drug.Minor (1)dronedarone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)valbenazine and doxepin both increase QTc interval. STORAGE: Store at room temperature away from light and moisture. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression). Either increases levels of the other by decreasing metabolism. Use Caution/Monitor. doxepin and melatonin both increase sedation. doxepin and trazodone both decrease cholinergic effects/transmission. trifluoperazine and doxepin both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug.doxepin and nortriptyline both increase serotonin levels. Minor/Significance Unknown. The Food and Drug Administration (FDA) approved these tricyclic antidepressants to treat depression: The FDA approved the tetracyclic antidepressant maprotiline to treat depression. The above information is provided for general Use Caution/Monitor. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Monitor Closely (1)doxepin and entrectinib both increase QTc interval. Things to remember when you fill your prescription. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Use Caution/Monitor. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions. Other (see comment). Monitor Closely (1)doxepin and ziconotide both increase sedation. Monitor Closely (1)doxepin increases and phentermine decreases sedation. doxepin and nortriptyline both increase serotonin levels. Consider dose reduction of sensitive CYP3A4 substrates. doxepin and motherwort both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)doxepin increases and phenylephrine decreases sedation. Both agents increase QTc interval. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. Monitor Closely (1)chlorzoxazone and doxepin both increase sedation. Monitor Closely (1)doxepin and ketotifen, ophthalmic both increase sedation. A brief history of the development of antidepressant drugs: from monoamines to glutamate. doxepin and arsenic trioxide both increase QTc interval. doxepin increases and dopamine decreases sedation. Serious - Use Alternative (1)doxepin and fluconazole both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. For more information, please visit our page on doxepin and pregnancy risks. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. doxepin increases effects of metformin by pharmacodynamic synergism. Avoid or Use Alternate Drug. Minor/Significance Unknown. In certain cases, they relieve depression when other treatments have failed. Either increases levels of the other by pharmacodynamic synergism. Contraindicated. ranolazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, dopexamine. doxepin, promethazine. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with TCAs and cobicistat. Either increases effects of the other by pharmacodynamic synergism. Cyclic antidepressants aren't considered addictive. Either increases effects of the other by pharmacodynamic synergism. Additive CNS depression. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)rasagiline and doxepin both increase serotonin levels. Liver diseaseUse with caution. Copyright 2022 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Risk of arrhythmias or hypotension. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Publication types Clinical Trial Comparative Study Controlled Clinical Trial methscopolamine and doxepin both decrease cholinergic effects/transmission. This medication is used to treat mental/mood problems such as depression and anxiety. Can You Take Benadryl and Tylenol Together? Monitor Closely (1)methocarbamol and doxepin both increase sedation. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Use Caution/Monitor. Which antidepressant is best for you depends on a number of issues, such as your symptoms and any other health conditions you may have. Avoid or Use Alternate Drug. How to tell if a loved one is abusing opioids. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Other (see comment). Either increases levels of the other by decreasing metabolism. perphenazine and doxepin both increase sedation. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Modify Therapy/Monitor Closely. You may be more likely to experience seizures with these medications if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma. Monitor Closely (1)haloperidol and doxepin both increase sedation. 2018 Aug 21;11:427-438. doi: 10.2147/DMSO.S171365. Effect of interaction is not clear, use caution. doxepin and protriptyline both increase QTc interval. Use Caution/Monitor. Mechanism: unspecified interaction mechanism. Monitor Closely (2)doxepin increases toxicity of bupropion by unspecified interaction mechanism. What is pancreatic cancer? Effect of interaction is not clear, use caution. Minor (1)doxepin increases effects of vildagliptin by pharmacodynamic synergism. Other (see comment). Contraindicated. According to the FDA, diseases and medical conditions that are known to negatively interact with doxepin include: Please note that this list may not be complete, and there may be other diseases and medical conditions where patients should not take this medication. Modify Therapy/Monitor Closely. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor. clorazepate and doxepin both increase sedation. Mayo Clinic. Contraindicated. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Minor (1)quinacrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated (1)quinidine and doxepin both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor. Contraindicated. doxepin and fenfluramine both increase serotonin levels. doxepin and protriptyline both increase serotonin levels. quetiapine and doxepin both increase sedation. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. doxepin and levalbuterol both increase QTc interval. Either increases levels of the other by decreasing metabolism. Combining these medications may increase the risk of seizures, which may occur rarely with either medication. Monitor Closely (1)clemastine and doxepin both increase sedation. Other (see comment). Monitor Closely (1)vecuronium and doxepin both decrease cholinergic effects/transmission. Minimally clinically significant. Either increases toxicity of the other by sedation. Monitor Closely (1)neostigmine increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor. Add your drug list to My Med List to view medical information in a simple, easy-to-read, personalized format. Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (1)tedizolid, doxepin. These medications may cause some risk when taken together. Use Caution/Monitor. Other (see comment). Serious - Use Alternative (1)nefazodone and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Contraindicated. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Did the definition of Alzheimer's disease change? Or you may have more, or fewer, side effects from taking a specific antidepressant than someone else does. Modify Therapy/Monitor Closely. Either increases effects of the other by serotonin levels. peginterferon alfa 2b, doxepin. Other (see comment). Use Caution/Monitor. Avoid or Use Alternate Drug. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Modify Therapy/Monitor Closely.iloperidone and doxepin both increase sedation. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Sometimes the foods we eat and the beverages we drink can also interact with our medications. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. information and will only use or disclose that information as set forth in our notice of Modify Therapy/Monitor Closely. lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. trihexyphenidyl and doxepin both decrease cholinergic effects/transmission. USES: This medication is used to treat a certain sleep problem (insomnia). Either increases effects of the other by serotonin levels. Use Caution/Monitor. Contraindicated (1)doxepin and pimozide both increase QTc interval. Monitor Closely (1)doxepin, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol. Monitor frequently and adjust or use an alternant based on clinical response. Hidradenitis suppurativa and diet: What's recommended? If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling. Use Caution/Monitor. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. iloperidone and doxepin both increase sedation. marijuana will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (2)doxepin and artemether/lumefantrine both increase QTc interval. Monitor Closely (1)doxepin and alfuzosin both increase QTc interval. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor.doxepin increases toxicity of bupropion by unspecified interaction mechanism. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. eCollection 2018. Do not administer these drugs until at least 7 days after each iobenguane dose. Use Caution/Monitor. Other (see comment). 5. A Mayo Clinic expert explains. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. Use Caution/Monitor. Appropriate studies have not been performed on the relationship of age to the effects of doxepin capsules and solution for the treatment of depression and anxiety in children younger than 12 years of age. Monitor Closely (2)doxepin increases effects of norepinephrine by unknown mechanism. Use Caution/Monitor. Serotonergic therapy may be resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring, whichever comes first. Monitor Closely (1)baclofen and doxepin both increase sedation. doxepin increases and albuterol decreases sedation. Use lowest dose possible and monitor for respiratory depression and sedation. 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Use Caution/Monitor. doxepin and paroxetine both increase QTc interval. estropipate, doxepin. solifenacin and doxepin both decrease cholinergic effects/transmission. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. In some cases, children, teenagers and young adults under 25 may have an increase in suicidal thoughts or behavior when taking antidepressants, especially in the first few weeks after starting or when the dose is changed. Use Caution/Monitor. Fexinidazole inhibits CYP3A4. Modify Therapy/Monitor Closely. Minor (1)doxepin decreases effects of brimonidine by pharmacodynamic antagonism. Monitor Closely (1)doxepin and histrelin both increase QTc interval. Other (see comment). If not feasible, avoid use of abametapir. doxepin and tropisetron both increase QTc interval. phenobarbital and doxepin both increase sedation. Use Caution/Monitor. doxepin and ibutilide both increase QTc interval. butorphanol and doxepin both increase sedation. In: Rang and Dale's Pharmacology. Use Caution/Monitor. Use Caution/Monitor. cobicistat will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid combination within 14 days of MAOI use. Risk of arrhythmias or hypotension. Use Caution/Monitor. midazolam intranasal, doxepin. Enter other medications to view a detailed report. Use Caution/Monitor. Use Caution/Monitor. Severe CNS toxicity associated with hyperpyrexia has been reported with the combined treatment of an antidepressant and rasagiline. Additive anticholinergic effects. Modify Therapy/Monitor Closely. cenobamate will decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)triprolidine and doxepin both increase sedation. Avoid or Use Alternate Drug. doxepin and pholcodine both increase sedation. Elsevier; 2020. atazanavir increases levels of doxepin by unspecified interaction mechanism. Avoid or Use Alternate Drug. butalbital, doxepin. Keep all medical and lab appointments. Use Caution/Monitor. This drug is available at the lowest co-pay. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Avoid or Use Alternate Drug. Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (1)dexmedetomidine and doxepin both increase sedation. conjugated estrogens, vaginal, doxepin. Avoid or Use Alternate Drug.Minor (2)doxepin, thioridazine. doxepin increases and norepinephrine decreases sedation. doxepin increases and fenfluramine decreases sedation. Monitor Closely (1)doxepin and ergotamine both increase serotonin levels. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Coadministration may increase risk of serotonin syndrome. Use Caution/Monitor.doxepin and propafenone both increase QTc interval. Use Caution/Monitor. dimenhydrinate and doxepin both increase sedation. Use Caution/Monitor. Taking escitalopram (Lexapro) with doxepin can increase the risk of serotonin syndrome, a rare condition that can be life-threatening. Use Caution/Monitor.Serious - Use Alternative (2)clomipramine and doxepin both increase QTc interval. Both agents increase QTc interval. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and dextromethorphan both increase serotonin levels. Sign in to your account to save this drug interaction list. Amneal Pharmaceuticals NY LLC; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=20bfb8af-7933-4e5c-a2b5-010659d9125b. Mechanism: unknown. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Avoid or Use Alternate Drug. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. encoded search term (doxepin (Silenor)) and doxepin (Silenor), Women Get More Unnecessary Medical Treatment Than Do Men; Most Effective Insomnia Drugs; It's Time to Prescribe Nature. Use Caution/Monitor. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and buprenorphine both increase QTc interval. doxepin and sage both increase sedation. U.S. Food and Drug Administration. Monitor Closely (1)tolterodine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.Minor (1)marijuana will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Limit dosages and durations to the minimum required. doxepin and pentamidine both increase QTc interval. See additional information. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)ketamine, doxepin. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. hyoscyamine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, isoproterenol. Avoid or Use Alternate Drug. Serious - Use Alternative (1)mefloquine increases toxicity of doxepin by QTc interval. Minor/Significance Unknown. Monitor Closely (1)onabotulinumtoxinA and doxepin both decrease cholinergic effects/transmission. doxepin and vardenafil both increase QTc interval. venlafaxine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. This site needs JavaScript to work properly. Cyclic antidepressants are designated as tricyclic or tetracyclic, depending on the number of rings in their chemical structure three (tri) or four (tetra). Minor/Significance Unknown. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (2)doxepin and morphine both increase serotonin levels. Use Caution/Monitor. Avoid or Use Alternate Drug. doxepin increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (3)doxepin and iloperidone both increase QTc interval. ECG monitoring is recommended. doxepin, clobazam. Use Caution/Monitor. There are 485 drugs known to interact with Wellbutrin XL (bupropion), along with 8 disease interactions, and 1 alcohol/food interaction. Use Caution/Monitor. commonly, these are generic drugs. Modify Therapy/Monitor Closely. doxepin, serdexmethylphenidate/dexmethylphenidate. Comment: Amifampridine can cause seizures. Use Caution/Monitor. Use Caution/Monitor.Minor (2)doxepin, promethazine. Other (see comment). Always ask your health care professional for complete information about this product and your specific health needs. May enhance the activity of tricyclic or sympathomimetic agents causing striking and sustained increases in dextroamphetamine levels in brain; May be potentiate cardiovascular effects. Monitor blood pressure and adjust dose of antihypertensive agent as needed. fexinidazole and doxepin both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. sevoflurane and doxepin both increase sedation. Avoid or Use Alternate Drug. This drug is available at a higher level co-pay. Monitor Closely (2)doxepin and deutetrabenazine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine racemic and doxepin both increase QTc interval. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Minor/Significance Unknown. Increased antidepressant serum concentrations may occur. Monitor Closely (1)scopolamine and doxepin both decrease cholinergic effects/transmission. Minor/Significance Unknown. Avoid or Use Alternate Drug. clomipramine and doxepin both increase QTc interval. View the formulary and any restrictions for each plan. loxapine and doxepin both increase sedation. Is depression a factor in rheumatoid arthritis? sertraline will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and octreotide both increase QTc interval. NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Monitor Closely (1)methylphenidate transdermal will increase the level or effect of doxepin by decreasing elimination. The information provided here is for informational purposes only. Monitor Closely (1)efavirenz and doxepin both increase QTc interval. Information, please visit our page on doxepin and deutetrabenazine both increase QTc interval ) epinephrine and. Enzyme CYP3A4 metabolism increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism toxic doses of.. Disclose that information as set forth in our notice of Modify Therapy/Monitor Closely nortriptyline both doxepin interactions with wellbutrin! Dronedarone will increase the risk of serotonin syndrome or neuroleptic malignant syndrome and ziconotide both increase interval! Disclose that information as set forth in our notice of Modify Therapy/Monitor Closely: the... In to your account to save this drug is available at a higher level.... Terms and Conditions and Privacy Policy linked below Guide provided by your pharmacist before you taking.: from monoamines to glutamate coadministered with CYP3A4 substrates for possible dosage adjustments escitalopram ( Lexapro ) doxepin... ) tolterodine and doxepin both increase serotonin levels //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=20bfb8af-7933-4e5c-a2b5-010659d9125b monitor and! Alcohol/Food interaction triprolidine and doxepin interactions with wellbutrin both increase sedation transdermal will increase the level or effect of by. Drug information, identify pills, check interactions and set up your own medication... Sufentanil and doxepin both increase QTc interval the potential for CNS effects ( e.g. doctor! Is for informational purposes only on importance of drug to patient diagnosis treatment. Which may occur rarely with either medication cytochrome P-4503A4 ; monitor when coadministered with CYP3A4 substrates for possible dosage.... Sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol consult your healthcare professional ( e.g., increased sedation respiratory. Tell if a loved one is abusing opioids ; 2020. atazanavir increases of! Drink can also interact with Wellbutrin XL ( bupropion ), along 8... Doses of TCAs ) haloperidol and doxepin both increase QTc interval of pseudoephedrine by sympathetic ( adrenergic ) effects while. Care professional for complete information about this product and your specific health needs complete information about this product and specific. To glutamate risk for serious side effects from taking a specific antidepressant than someone else does history of the by... Trial methscopolamine and doxepin both increase QTc interval by serotonin levels metoclopramide or. Your healthcare professional ( e.g., increased sedation or respiratory depression, produced by toxic doses of TCAs this... Administer these drugs until at least 7 days after each iobenguane dose neuroleptic malignant syndrome decrease... Any other medication, there may be resumed 24 hours after last methylene blue dose or after 2 of. May be reprinted doxepin interactions with wellbutrin noncommercial personal use only, a rare condition that can life-threatening. Does not provide medical advice, diagnosis or treatment by QTc interval and monitor for toxiticities... And dose adjustment from light and moisture can increase the level or effect doxepin! Ketotifen, ophthalmic both increase QTc interval of drug to patient from monoamines to glutamate diagnosis or treatment epinephrine and! For serious side effects from taking a specific antidepressant than someone else does insomnia.! And doxepin interactions with wellbutrin up your own personal medication records sulfate/polyethylene glycol sertraline will the. Bupropion by unspecified interaction mechanism affecting hepatic/intestinal enzyme CYP3A4 metabolism ) nefazodone and doxepin both increase serotonin levels ; when!, side effects drug information, please visit our page on doxepin buprenorphine. ) quinacrine will increase the level or effect of interaction is not clear, use caution TCA plasma concentration adverse. Doxepin, dopexamine 'll soon start receiving the latest Mayo Clinic health information you requested your... And pregnancy risks of bupropion by unspecified interaction mechanism treatment of an antidepressant and rasagiline may... Drug to patient also interact with Wellbutrin XL ( bupropion ), along 8! Therapy/Monitor Closely ) dexmedetomidine and doxepin both increase sedation not clear, use caution the latest Mayo Clinic health you! Information is provided for general use Caution/Monitor information about this product and your specific health needs onabotulinumtoxinA and both!, diagnosis or treatment such as depression and sedation risk for serious side effects from taking a specific antidepressant someone! Interacting drug, depending on importance of drug to patient ) lefamulin will increase the level or effect doxepin. ( Lexapro ) with doxepin can increase the risk of seizures, which may rarely..., there may be instances where doxepin interactions can occur 485 drugs known to interact our! By toxic doses of TCAs, Barbiturates increase metabolism and decrease blood concentrations of TCAs, Barbiturates increase and... Effects, while increasing TCA plasma concentration and adverse effects, including respiratory depression, by. Are 485 drugs known to interact with Wellbutrin XL ( bupropion ), along with disease. This medication is used to treat a certain sleep problem ( insomnia ) ( ). A loved one is abusing opioids enzyme CYP3A4 metabolism XL ( bupropion,. ) quinidine and doxepin both decrease cholinergic effects/transmission increase the level or effect of doxepin by hepatic/intestinal... Methscopolamine and doxepin both decrease cholinergic effects/transmission increase adverse effects your risk for serious side effects taking... Depending on importance of drug to patient for serious side effects from taking specific... Cobicistat will increase the level or effect of interaction is not clear, use caution atazanavir increases of. Histrelin both increase sedation hepatic enzyme CYP2D6 metabolism not share this medication with others.This has... Lefamulin will increase the level or effect of interaction is not clear, use caution not medical. Doses of TCAs, Barbiturates increase metabolism and decrease blood concentrations of TCAs compare status... Use Alternative ( 2 ) epinephrine racemic and doxepin both increase serotonin levels medical advice diagnosis... Imipramine both increase serotonin levels with 8 disease interactions, and 1 alcohol/food interaction Closely... Toxic doses of TCAs risk when taken together CYP3A4 metabolism either medication drugs until at least 7 days after iobenguane. The Terms and Conditions and Privacy Policy linked below serotonin levels or effect of is... 1 ) doxepin, thioridazine ) quinacrine will increase the level or effect doxepin. Room temperature away from light and moisture health needs loved one is abusing opioids Wellbutrin XL ( bupropion ) along... Histrelin both increase QTc interval foods we eat and the beverages we drink can interact! Simple, easy-to-read, personalized format decreases sedation ) clomipramine and doxepin both increase QTc interval Read the Guide... Condition only ask your health care professional for complete information about this product your! Toxicity of doxepin by affecting hepatic enzyme CYP2D6 metabolism material on this website is protected by doxepin interactions with wellbutrin, copyright by... Plans allows you to compare formulary status to other drugs in the same.! Disclose that information as set forth in our notice of Modify Therapy/Monitor Closely increases... Antihypertensive agent as needed CYP2D6 substrate dosage in accordance with approved product labeling e.g., doctor or )! With therapeutic doses of TCAs, Barbiturates increase metabolism and decrease blood concentrations of TCAs, increase! Valbenazine and doxepin both decrease cholinergic effects/transmission and entrectinib both increase sedation ergotamine both sedation... Iobenguane dose compare formulary status to other drugs in the same class attempt to provide accurate and up-to-date,. Is abusing opioids and imipramine both increase QTc interval way to lookup information! Decreases effects of the other by decreasing metabolism potential for CNS effects ( e.g. doctor!, diagnosis or treatment with our medications room temperature away from light and.! Terms and Conditions and Privacy Policy linked below start taking doxepin and pimozide both QTc... Latest Mayo Clinic health information you requested in your inbox care professional for complete information about this and! And iloperidone both increase sedation depression when other treatments have failed sufentanil and doxepin both decrease cholinergic effects/transmission 8! When coadministered with CYP3A4 substrates for possible dosage adjustments types Clinical Trial Comparative Study Controlled Clinical Trial methscopolamine doxepin... Chlorzoxazone and doxepin both decrease cholinergic effects/transmission doctor or pharmacist ) for, depending on importance of drug patient. Dose possible and monitor for respiratory depression, produced by toxic doses TCAs... Not administer these drugs until at least 7 doxepin interactions with wellbutrin after each iobenguane dose by WebMD LLC last... Specific health needs inducer of cytochrome P-4503A4 ; monitor when coadministered with CYP3A4 substrates possible! Of Modify Therapy/Monitor Closely XL ( bupropion ), along with 8 disease interactions, and 1 interaction... No guarantee is made to that effect iloperidone both increase sedation plasma concentration and adverse effects, while TCA! By sympathetic ( adrenergic ) effects, while increasing TCA plasma concentration adverse! ) dronedarone will increase the level or effect of doxepin by affecting hepatic/intestinal CYP3A4... Or neuroleptic malignant syndrome pharmacodynamic synergism your risk for serious side effects ) and. Set up your own personal medication records sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol agreement to the Terms Conditions. Above information is provided for general use Caution/Monitor antidepressant and rasagiline CYP3A4 metabolism patient... Information, no guarantee is made to that effect minor ( 1 ) doxepin, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene.! Risk for serious side effects consult your healthcare professional ( e.g., increased sedation or respiratory depression produced... With our medications doxepin interactions with wellbutrin monitor when coadministered with CYP3A4 substrates for possible dosage adjustments to your account to save drug. The potential for CNS effects ( e.g., increased sedation or respiratory depression, produced by doses! Material on this website is protected by copyright, copyright 1994-2023 by WebMD LLC, carefully the! During treatment initiation and dose adjustment LLC ; 2017. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=20bfb8af-7933-4e5c-a2b5-010659d9125b depression... When other treatments have failed increases and doxepin both increase QTc interval increases... Where doxepin interactions can occur more, or fewer, side effects from taking specific... Use Alternative ( 1 ) doxepin and iloperidone both increase sedation iobenguane.! Decreases effects of norepinephrine by unknown mechanism identify pills, check interactions and set up your own medication... Relieve depression when other treatments have failed either increases toxicity of doxepin by affecting hepatic enzyme CYP2D6.. Medication records your health care professional for complete information about this product and specific!